1/4/2024 0 Comments Heparin antidote vitamin k![]() ![]() Protamine sulphate – this is only required in severe bleeding cases where there is likely to be a large amount of circulating heparin.It has a short elimination half-life of 30–90 minutes, although may be longer in renal failure. General management and drug therapy Heparin reversal Intravenous unfractionated heparin vitamin K may be needed (dosing details can be found below). If the patient is being anticoagulated with warfarin, a small dose of reversing agent i.e. Patients with minor bleeding, or over-anticoagulated without any bleeding, will usually require temporary cessation of anticoagulant therapy to achieve a low-therapeutic level of anticoagulation. Patients with major or life-threatening bleeding, irrespective of their indication for anticoagulation (even patients with prosthetic metal heart valves) will usually require complete reversal of their anticoagulant therapy, at least temporarily. The peri-operative anticoagulant management of patients receiving warfarin is covered in detail here. The general principles are similar in each situation and all cases require an individualised risk:benefit assessment. Reversal of anticoagulant therapy may be necessary when a patient is found to be over-anticoagulated, develops bleeding problems or requires an invasive procedure. ![]() Reversal of Antithrombotic Therapies Introduction ![]()
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